Effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the behavioral effects of cocaine in rats.

摘要: The efficacy of 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), a member endogenous tetrahydroisoquinolines, in cocaine- and food-maintained responding self-administration procedures under fixed ratio 5 schedule reinforcement as well cocaine food seeking behaviors male Wistar rats was examined. effects 1MeTIQ on discrimination basal locomotor activity were also assessed. In trained to self-administered either (0.5 mg/kg/injection) paired with the cue (light+tone) or reinforcement, (25 - 50 mg/kg) dose-dependently decreased cocaine-maintained responding, but did not alter responding. behavior reinstated by noncontingent presentation (10 mg/kg, i.p.), altered neither discrete (tone+light) nor food-induced reinstatement. discriminate from saline water-reinforced 20 task, pretreatment resulted substitution significant alterations (1.25 10 mg/kg)-induced discriminative stimulus effects. produce changes horizontal activity. conclusion, our present results outline significance exogenously applied attenuating drug-evoked relapses direct rewarding properties (that model cocaine-induced "high"), subjective Moreover, dissociation between vs. demonstrated.