Endovascular Stents: Preliminary Clinical Results and Future Developments

摘要: Summary: At present, there is an exponential use of new interventional techniques whose proper role and value have not yet been defined. The intracoronary stent just one example. There no doubt that stents can be implanted with a high technical success rate associated highly predictable immediate angiographic results they appear to superior all other techniques. However, the intrinsic thrombogenicity devices cmntly available for clinical warrants vigorous anticoagulation, exposing patient either risk (sub)acute thrombosis or hemorrhage vascular complications. It remains determined whether implantation will reduce incidence restenosis this in improved long-term event symptom-free survival. Experimental studies indicate thrombogenic nature may controlled by coating struts endothelial cells polymers. With respect restem sis, it evident as long mechanical injury applied vessel wall, wall respond neointimal thickening. has potential control tissue response serving carrier local antiproliferative drug delivery eventually genetic manipulation. intensive research which now going on Combination experimental animal data, human postmortem pathologic observations, yielding clear insights future directions address these issues.