Restenosis after Palmaz-Schatz™ Stent Implantation

摘要: Efforts currently directed at reducing restenosis in coronary arteries after transcatheter interventions have met with little success. A variety of pharmacologic [1–6] and mechanical [7–11] been tested but without proven benefit. This failure to prevent should not be surprising given our limited understanding the complexity biologic response arterial injury. injury phenomenon occurs independent specific type intervention is a result plaque disruption subintimal injury, endothelial denudation, platelet activation release growth factors which lead intimal smooth muscle cell proliferation. has described as an example “wound healing” [12]. It would simplistic expect that any available device abolish problem restenosis. The best could do provide larger smoother initial lumen compared standard balloon angioplasty. enhanced acute gain diameter accommodate greater degree hyperplasia before hemodynamically significant luminal compromise occur. Coronary stents are permanent implants this “growing room” for cells may potentially reduce rate by effect. purpose chapter review results angiographic follow-up studies one intravascular scaffold, expandable Palmaz-SchatzTM stent.