Physiological roles of somatocrinin and somatostatin in the regulation of growth hormone secretion.

摘要: Abstract Somatocrinin, a 44 amino acid peptide with potent growth hormone (GH) releasing activity in anesthetized rats, was tested conscious freely-moving rats. When high doses of 1 to 10 μg were administered (iv) at random times between spontaneous GH pulses, the responses inconsistent. similar under identical conditions but rats pretreated antibodies against somatostatin, all animals demonstrated marked and immediate increase plasma 5 fold. Similarly, dose somatocrinin also ineffective increasing when subjected 72 h fast, paradigm known enhance endogenous somatostatin secretion. However, increased over 20 fold if somatostatin. These results demonstrate dynamic opposite roles exerted by regulating