Cerebral 5-HT2A receptor binding is increased in patients with Tourette's syndrome.

摘要: Experimental and clinical data have suggested that abnormalities in the serotonergic neurotransmissions frontal-subcortical circuits are involved Tourette's syndrome. To test hypothesis brain's 5-HT2A receptor binding is increased patients with syndrome, PET imaging was performed. Twenty adults syndrome 20 healthy control subjects were investigated PET- ( 18 F)altanserin using a bolus-infusion protocol. Regions of interest delineated automatically on co-registered MRI images, partial volume-corrected parameters extracted from images. Comparison between showed specific binding, not only a-priori selected brain regions hypothesized to be but also post-hoc analysis global up-regulation when testing for overall difference randomization (p<0.03). Increased found closely related subcortical most other regions. Our suggest transmitter system pathophysiologically trial antagonists may justified.