5-HT radioligands for human brain imaging with PET and SPECT.
作者： Louise M. Paterson , Birgitte R. Kornum , David J. Nutt , Victor W. Pike , Gitte M. Knudsen
DOI: 10.1002/MED.20245
关键词:
摘要: The serotonergic system plays a key modulatory role in the brain and is target for many drug treatments disorders either through reuptake blockade or via interactions at 14 subtypes of 5-HT receptors. This review provides history current status radioligands used positron emission tomography (PET) single photon computerized (SPECT) imaging human serotonin (5-HT) receptors, transporter (SERT), synthesis rate. Currently available vivo humans include antagonists 5-HT(1A), 5-HT(1B), 5-HT(2A), 5-HT(4) SERT. Here we describe evolution these radioligands, along with attempts made to develop additional targets. We properties needed radioligand become successful main caveats. success PET SPECT can ultimately be assessed by its frequency use, utility humans, number research sites using it relative invention date, so aspects are also covered. In conclusion, development image targets high interest, evaluation leading invaluable insight into normal abnormal function, emphasizing need continued both imaging.
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