Evolutionary implications of inversions that have caused intra-strand parity in DNA.

摘要: Chargaff's rule of DNA base composition, stating that comprises equal amounts adenine and thymine (%A = %T) guanine cytosine (%C %G), is well known because it was fundamental to the conception Watson-Crick model structure. His second parity proportions double-stranded are also reflected in single-stranded %T, %C %G) more obscure, likely its biological basis significance still unresolved. Within each strand, symmetry single nucleotide composition extends even further, being demonstrated balance di-, tri-, multi-nucleotides with their respective complementary oligonucleotides. Here, we propose inversions sufficient account for within DNA. Human mitochondrial does not demonstrate such intra-strand parity, consider how different functional drivers may relate our theory. This concept supported by recent observation occur frequently. Along chromosomal duplications, must have been shaping architecture genomes since origin life.