Characteristics of oligonucleotide frequencies across genomes: Conservation versus variation, strand symmetry, and evolutionary implications

作者: Shang-Hong Zhang , Ya-Zhi Huang

DOI: 10.1038/NPRE.2008.2146.1

关键词:

摘要: One of the objectives evolutionary genomics is to reveal genetic information contained in primordial genome (called primary this paper, with defined here as most primitive nucleic acid for earth’s life) by searching traits or relics remained modern genomes. As shorter a sequence is, less probable it would be modified during evolution. For that reason, some characteristics very short nucleotide sequences have considerable chances persist billions years Consequently, conservation certain genomic features mononucleotides, dinucleotides, and higher-order oligonucleotides across various genomes may exist; some, if not all, these information. Based on assumption, we analyzed pattern frequencies whole-genome from 458 species (including archaea, bacteria, eukaryotes). Also, studied phenomenon strand symmetry The results show dinucleotides does exist, ubiquitous explicit contribute frequency conservation. We propose new hypothesis origin well constitution early conclude phenomena original

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