Frequent Loss of Heterozygosity at the DCC Locus in Gastric Cancer
作者： Setsuo Hirohashi , Hitoshi Tsuda , Takao Saito , Masaaki Terada , Jun Yokota
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摘要: We examined 28 cases of surgically resected gastric cancer, excluding the diffuse type, for loss heterozygosity (LOH) on 12 chromosomal arms using polymorphic DNA markers. LOH chromosome 18q was detected in 61% (14 23) by probes OLVIIA8, OLVIIE10, p15–65, SAM 1.1, and OS-4, a putative common region showing included locus DCC tumor suppressor gene. 17p also frequently found (8 19 or 42% cases) p10–3 pHF12–1, 5 these 6 accompanied 18q. On other hand, incidence 30% less pHRnES, pHF12–65, p-c-mybE2.6, NJ3 3.2, pHF12–8, pHINS6.0, p9D11, hp2-α, pCMM6, P1A5 chromosomes 1q, 5, 6q, 7q, 9, 11p, 13q, 16q, 20, 22q, respectively. frequent irrespective depth invasion, whereas higher which invaded beyond muscularis propria than those invasion limited to submucosa propria. These results suggest that occurs at an earlier stage inactivation genes located ( e.g. , p53 genes) is critically involved development majority cancers. While alteration gene observed various human cancers, considered occur more selectively gastrointestinal
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