The effects of variations in tissue microstructure from postmortem rat brain on the asymmetry of the water proton resonance
作者： Sean Foxley , Gregory S Karczmar , Kazutaka Takahashi
DOI: 10.1002/MRM.27338
关键词:
摘要: PURPOSE This work was performed to investigate the effects of tissue microstructure from postmortem rat brain on shape water proton spectrum. METHODS Perfusion-fixed, resected brains (N = 4) were imaged at 9.4T. 3D DTI and echo-planar spectroscopic imaging (EPSI) data acquired with 150 μm isotropic resolution. over 60 directions b = 3000 s/mm2 . Water spectra produced EPSI 128 echoes, 2.9 Hz spectral A voxel-wise metric reflecting asymmetry about peak resonance computed compared orientation estimates by fitting susceptibility anisotropy model. RESULTS Asymmetric broadening for mixed populations grey and/or white matter as determined thresholding fractional anisotropy. Asymmetry shown be differentially affected tract relative B0 in high FA voxels, whereas low voxels exhibited little sensitivity. Anatomic structures hippocampus also found produce distinct changes resonance. CONCLUSION Present results demonstrate that structural variations architecture cause characteristic, reproducible shape. suggests are sensitive cytoarchitectural tissue.
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