The 'skinny' on childhood obesity: how our western environment starves kids' brains.

摘要: In this review, the mechanism of our "toxic environment's" effects on insulin and weight gain in genesis obesity is elaborated. The composition diet highly insulinogenic. drives energy into fat, interferes with leptin signaling VMH. This results sense starvation, which decreased SNS activity, reducing expenditure physical activity; increased vagal promotes yet further release storage. Thus, hyperinsulinemia turns negative feedback system a "vicious cycle" (see Figure 3, page 905). Externally, appears as "gluttony sloth" but it biochemically driven. How does work? A thin, insulin-sensitive, 13-year-old boy might consume daily allotment 2,000 kcal, burn kcal (or 50 kcal/kg fat-free mass) order to remain weight-stable, stable level. However, if that same became hyperinsulinemic and/or resistant, perhaps many 250 would be shunted storage adipose tissue, promoting persistent obligate gain. Due storage, he now only has 1,750 per day burn. also lower level signal transduction, conveying CNS insufficiency. remaining calories available are than his expenditure; starvation. Through tone, reduce resulting quality life; through increase caloric intake secretion, at much higher vicious cycle gluttony, sloth, promulgated. Is personal responsibility, when kid's brain thinks it's starving? responsibility American Academy Pediatrics still recommends juice for toddlers? Women, Infant Children program subsidizes fruit not fruit? first ingredient barbecue sauce high-fructose corn syrup? high-fiber fresh produce unavailable poor neighborhoods? local fast food restaurant neighborhood venue clean air-conditioned? meet criteria No Child Left Behind, school away education class? children allowed out house play fear crime? We must get down. Fixing environment" by altering supply activity all can't done government, won't Big Food. will require grassroots, bottom-up effort part parents community leaders. pediatricians lead way.