p53 Protein Accumulates Frequently in Early Bronchial Neoplasia

摘要: Abstract p53 mutations are common in human lung cancer and frequently generate levels of protein that detectable by immunohistochemistry. For this reason, accumulation is a candidate biomarker, but little known about its timing or frequency multistage bronchial carcinogenesis. We studied tissues containing preinvasive squamous neoplasms from 34 donors with without cancer. Nuclear was present 0% normal mucosas, 6.7% metaplasias, 29.5% mild dysplasias, 26.9% moderate 59.7% severe 58.5% carcinomas situ, 67.5% microinvasive carcinomas, 79.5% invasive tumors. These data indicate (a) accumulates 30% the earliest recognized neoplastic lesions (i.e., dysplasia), (b) there an increasing starting dysplasia, (c) infrequently metaplastic mucosa. In subset six patients whose most advanced lesion carcinoma situ evidence cancer, detected 8.3% 37.5% 12.5% 93.8% 55% lesions. show clearly alterations can occur before invasion suggest similar to observed full series. Since two-thirds more cancers have alterations, make tumor suppressor gene attractive marker for early diagnosis evaluation chemoprevention agents.