TP53 mutations in upper aerodigestive squamous cell carcinomas from a group of Brazilian patients.
作者： Maria A. Nagai , Elizabete C. Miracca , Lidia Yamamoto , Luiz P. Kowalski , Ricardo R. Brentani
DOI: 10.1016/S0002-9610(99)80337-7
关键词:
摘要: Background: Loss of function the tumor suppressor gene TP53 contributes to development several tumors. Patients and methods: We screened DNA samples from 47 patients with upper respiratory system squamous cell carcinomas for presence mutations. Exons 4 8 were amplified by polymerase chain reaction, mutations identified single-strand conformation polymorphism analysis. Results: The demonstrated in 23 cases (49%). Mutations distributed as follows: exon 4, 5 cases; 5, 6, 6 7, 8, cases. Demographic variables, site, stage, family history cancer, tobacco smoking not predictors There was an increasing number more undifferentiated tumors ( P = 0.0595). Conclusions: These findings suggest that are associated differentiation, but risk lymph node metastasis group analyzed.
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