Genetic determinants in head and neck squamous cell carcinoma and their influence on global personalized medicine

摘要: While sequencing studies have provided an improved understanding of the genetic landscape head and neck squamous cell carcinomas (HNSCC), there remains a significant lack data derived from non-Caucasian cohorts. Additionally, is wide variation in HNSCC incidence mortality worldwide both between within various geographic regions. These epidemiologic differences are part accounted for by varying exposure to environmental risk factors such as tobacco, alcohol, high human papilloma viruses betel quid. However, inherent may also play important role this variability. As limited available many populations, involvement unique pathogenesis epidemiologically diverse groups unknown. Here, we review current knowledge about epidemiologic, environmental, cohorts globally discuss future necessary further our these differences. Long-term, more complete drivers found help development personalized medicine protocols patients with rare or complex events.