Cardiovascular complications in atypical haemolytic uraemic syndrome

摘要: Haemolytic uraemic syndrome (HUS) is characterized by nonimmune haemolytic anaemia, thrombocytopenia and renal impairment-most incidents in childhood are caused shiga toxin-producing bacteria. Atypical HUS (aHUS) accounts for 10% of cases has a poor prognosis. About 60% patients with aHUS have dysregulation the alternative complement pathway (complement-mediated aHUS). The kidney main target organ, but other organs might also be affected. Cardiac complications occur 3-10% complement-mediated aHUS, as consequence microangiopathic injury coronary microvasculature, can cause sudden death. Emerging evidence suggests that either thrombosis or stenosis medium large arteries complicate disease course, such disorders even after function lost. In this Perspectives article we discuss impact cardiovascular involvement role acute chronic hyperactivation events implications treatment.