Analysis of ambulatory blood pressure data in antihypertensive drug trials

摘要: In recent years a number of different methods have been evolved to analyse ambulatory blood pressure monitoring data, particularly for evaluating the relationship between and target-organ disease assessing effects antihypertensive drug therapy. The most commonly used include calculation mean or median values during wakefulness sleep, assessment variability distribution, calculating load, and, more recently, integrating area under curve over time. Although all these data analysis merit, none has exclusively in rationale using particular method should be based on physiological pharmacological modality investigation, reproducibility method, ease statistical manipulation important, determinant indices hypertensive process (e.g. left ventricular enlargement, vascular compliance). Ambulatory recordings are superior clinic duration activity an drug, while Fourier transformation individual curves (in contrast group curves) may aid evaluation peak trough activity. As load closely related hypertension, use is advocated efficacy drugs.