Extracellular Vesicles as Potential Theranostic Platforms for Skin Diseases and Aging.

作者: Hyosuk Kim , Kwangmeyung Kim , Yoosoo Yang , Sun Hwa Kim , Jong Won Lee

DOI: 10.3390/PHARMACEUTICS13050760

关键词:

摘要: Extracellular vesicles (EVs), naturally secreted by cells, act as mediators for communication between cells. They are transported to the recipient cells along with cargoes such nucleic acids, proteins, and lipids that reflect changes occurring within parent Thus, EVs have been recognized potential theranostic agents diagnosis, treatment, prognosis. In particular, evidence accumulated date suggests an important role of in initiation progression skin aging various diseases, including psoriasis, systemic lupus erythematosus, vitiligo, chronic wounds. This review highlights recent research investigates their biomarkers therapeutic diseases aging.

参考文章(135)
Arsalan Shabbir, Audrey Cox, Luis Rodriguez-Menocal, Marcela Salgado, Evangelos Van Badiavas, Mesenchymal Stem Cell Exosomes Induce Proliferation and Migration of Normal and Chronic Wound Fibroblasts, and Enhance Angiogenesis In Vitro Stem Cells and Development. ,vol. 24, pp. 1635- 1647 ,(2015) , 10.1089/SCD.2014.0316
Santosh Bashyal, Sangkil Lee, Delivery of biopharmaceuticals using combination of liposome and iontophoresis: a review Journal of Pharmaceutical Investigation. ,vol. 45, pp. 611- 624 ,(2015) , 10.1007/S40005-015-0219-7
Naoko Inoue, Hiroaki Todo, Dai Iidaka, Yoshihiro Tokudome, Fumie Hashimoto, Tohru Kishino, Kenji Sugibayashi, Possibility and effectiveness of drug delivery to skin by needle-free injector International Journal of Pharmaceutics. ,vol. 391, pp. 65- 72 ,(2010) , 10.1016/J.IJPHARM.2010.02.019
Sigrid Hatse, Barbara Brouwers, Bruna Dalmasso, Annouschka Laenen, Cindy Kenis, Patrick Schöffski, Hans Wildiers, Circulating MicroRNAs as easy-to-measure aging biomarkers in older breast cancer patients: Correlation with chronological age but not with fitness/frailty status PLOS ONE. ,vol. 9, pp. 1- 9 ,(2014) , 10.1371/JOURNAL.PONE.0110644
Claudia Chavez-Muñoz, Ruhangiz T. Kilani, Aziz Ghahary, Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes Journal of Cellular Physiology. ,vol. 221, pp. 221- 231 ,(2009) , 10.1002/JCP.21847
Giovanna Leoni, Philipp-Alexander Neumann, Nazila Kamaly, Miguel Quiros, Hikaru Nishio, Hefin R. Jones, Ronen Sumagin, Roland S. Hilgarth, Ashfaqul Alam, Gabrielle Fredman, Ioannis Argyris, Emile Rijcken, Dennis Kusters, Chris Reutelingsperger, Mauro Perretti, Charles A. Parkos, Omid C. Farokhzad, Andrew S. Neish, Asma Nusrat, Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair Journal of Clinical Investigation. ,vol. 125, pp. 1215- 1227 ,(2015) , 10.1172/JCI76693
Daniel Muñoz-Espín, Manuel Serrano, Cellular senescence: from physiology to pathology Nature Reviews Molecular Cell Biology. ,vol. 15, pp. 482- 496 ,(2014) , 10.1038/NRM3823
Lahiru Gangoda, Stephanie Boukouris, Michael Liem, Hina Kalra, Suresh Mathivanan, Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic? Proteomics. ,vol. 15, pp. 260- 271 ,(2015) , 10.1002/PMIC.201400234
Veronica G. Beaudry, Laura D. Attardi, SKP-ing TAp63: stem cell depletion, senescence, and premature aging. Cell Stem Cell. ,vol. 5, pp. 1- 2 ,(2009) , 10.1016/J.STEM.2009.06.015
Cecele J. Denman, James McCracken, Vidhya Hariharan, Jared Klarquist, Kepa Oyarbide-Valencia, José A. Guevara-Patiño, I. Caroline Le Poole, HSP70i Accelerates Depigmentation in a Mouse Model of Autoimmune Vitiligo Journal of Investigative Dermatology. ,vol. 128, pp. 2041- 2048 ,(2008) , 10.1038/JID.2008.45