Kinetics of hepatocellular proliferation as a function of the microvascular structure and functional state of the liver.
作者： Hartmut M. Rabes
DOI: 10.1002/9780470720363.CH3
关键词:
摘要: An analysis of hepatocellular proliferation in regenerating rat liver reveals a dependence kinetic parameters on the microvascular structure liver. Influx kinetics hepatocytes into DNA synthesis as well cell cycle phases vary different parts lobule between afferent and efferent vascular poles. Heterogeneity proliferative response size limitations compartments appear to be intimately related actual functional state individual cell. Modifications functions result variations activity. Phenobarbital-induced hypertrophy permissive action G1- S influx. Selective destruction subpopulations, by allyl formate, leads new determination residual change compartments. Maximum modulation is obtained hydroxyurea-induced synchronization after partial resection. During hydroxyurea treatment, shows pronounced cellular hypertrophy. After release from block, cells embark simultaneously. The synthesizing compartment comprises almost entire population. Heptotrophic factors might play part regulating or modifying function loss.
sci-hub.st 参考文章(62)
Nancy L.R. Bucher, Regeneration of Mammalian Liver International Review of Cytology. ,vol. 15, pp. 245- 300 ,(1963) , 10.1016/S0074-7696(08)61119-5
H Popper, Pathologic aspects of cirrhosis. A review. American Journal of Pathology. ,vol. 87, pp. 228- 264 ,(1977)
M. F. Rajewsky, D. F. H�lser, E. Fabricius, [Studies on synchronisation in vivo: temporary inhibition of DNA synthesis in normal and malignant mammalian cell systems with hydroxyurea]. Zeitschrift für Krebsforschung. ,vol. 76, pp. 266- 292 ,(1971) , 10.1007/BF00304031
H.L. Leffert, K.S. Koch, 7 – CONTROL OF ANIMAL CELL PROLIFERATION Growth, Nutrition, and Metabolism of Cells in Culture. pp. 225- 294 ,(1977) , 10.1016/B978-0-12-598303-7.50013-8
Jan W. Steiner, Melville J. Phillips, Electron Microscopy of Liver Cells in Cirrhotic Nodules: I. The Lateral Cell Membranes American Journal of Pathology. ,vol. 46, pp. 985- 1005 ,(1965)
Van R. Potter, John H. Schneider, Alternative Pathways of Glucose Metabolism III. The Incorporation of Radioactivity from Glucose-1-C14 into the Nucleic Acids of Regenerating Rat Liver Cancer Research. ,vol. 17, pp. 701- 706 ,(1957)
A. B. Wittig, S. E. Shackney, S. S. Ford, The effects of counting threshold and emulsion exposure duration on the percent-labeled mitosis curve and their implications for cell cycle analysis. Cancer Research. ,vol. 33, pp. 2726- 2731 ,(1973)
S. Czichos, G. Iseler, H. M. Rabes, H. V. Tuczek, Synchronization of Hepatocellular DNA Synthesis in Regenerating Rat Liver by Continuous Infusion of Hydroxyurea Cancer Research. ,vol. 37, pp. 1105- 1111 ,(1977)
John Hilton, Alan C. Sartorelli, Induction by Phenobarbital of Microsomal Mixed Oxidase Enzymes in Regenerating Rat Liver Journal of Biological Chemistry. ,vol. 245, pp. 4187- 4192 ,(1970) , 10.1016/S0021-9258(18)62902-3
Van R. Potter, F J. Bollum, Nucleic acid metabolism in regenerating rat liver. VI. Soluble enzymes which convert thymidine to thymidine phosphates and DNA. Cancer Research. ,vol. 19, pp. 561- 565 ,(1959)