Kainic acid depresses the ex vivo release of dynorphin B and glutamate from rat hippocampal mossy fiber synaptosomes.
作者： Jeffrey N. Simpson , Robert L. Gannon , Jacqueline F. McGinty , David M. Terrian
DOI: 10.1016/0304-3940(92)90391-J
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摘要: Abstract This experiment examined the effects of intracerebroventricularly (i.c.v.) administered kainic acid (KA) on subsequent ex vivo release l -glutamate (Glu) and dynorphin B-like immunoreactivity (Dyn B-LI) from isolated rat hippocampal mossy fiber (MF) synaptosomes at 4.5 h, 20 h or 48 after administration 0.5 μg/μl KA. The Dyn B-LI content in synaptosomal fraction initially decreased then rebounded remained elevated above control levels h. K + -evoked was markedly depressed KA significantly below In contrast, caused no change Glu as compared to levels, but did result a significant decrease These data indicate persistent effect i.c.v. neurotransmission MF-CA3 synapses hippocampus, resulting suppression well opioid peptide, B.
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