The interaction between κ-opioid agonist, U-50,488H, and kainic acid: behavioral and histological assessments

摘要: Abstract The effects of a selective κ-agonist, U-50,488H, on systemic kainic acid-induced behavioral and histological changes were studied in rats. U-50,488H inhibited wet dog shakes naloxone reversible manner; however, U-50,448H did not protect rats against acid-evoked seizures. As revealed by analysis, acid caused edema severe neuronal damage several brain regions, notably CA1 but also the CA3 fields both hippocampi. Pretreatment with markedly protected hippocampal neurons, especially those CA1, neurotoxicity. Naloxone itself had little effect seizures or neuron loss. plus resulted less and, consequently, cell loss than after alone. These data indicate that can attenuate neurotoxic consequences administration. However, mechanism these requires further study more specific opioid antagonists.