Repeated ethanol administration decreases prodynorphin biosynthesis in the rat hippocampus.
作者： B. Przewłocka , W. Lasoń , R. Przewłocki
DOI: 10.1016/0304-3940(92)90515-9
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摘要: Abstract The effect of single and repeated (19 days) intragastric ethanol administration on prodynorphin mRNA α-neoendorphin levels in the hippocampus rat was studied using situ hybridization RIA methods, respectively. Single had no either these two parameters. Repeated decreased both immunoreactive (ir-) (by ca. 37%) 57%) levels. Two days after last dose changes ir-α-neoendorphin tissue content were found, whereas level remained 44%). These results suggest that evokes a long-lasting decrease biosynthesis hippocampal prodynorphin, this may play some role ethanol-induced deficiency neuronal functions.
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