Synthesis of optically active 3-oxa-carbacyclin precursors featuring asymmetric Horner-Emmons reaction

作者: Hans-Joachim Gais , Gerhard Schmiedl , Walter A Ball , Jörg Bund , Gunther Hellmann

DOI: 10.1016/S0040-4039(00)82039-0

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摘要: Abstract An enantioselective synthesis of 5 is described. Asymmetric Horner-Emmons reactions with the chiral phosphonate 6 are key steps in allylic alcohols E - 8 and 11 from ketones 9, respectively.

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