Staphylococcus aureus host range and human-bovine host shift.

摘要: Staphylococcus aureus is a major agent of bovine mastitis. The concomitant emergence pig-associated methicillin-resistant S. (MRSA) in human carriage and infection requires reexamination the host range specificity human- cow-associated strains, something which has not been systematically studied previously. genetic relatedness 500 isolates from mastitis cases, 57 nasal farmers, 133 nonfarmers was determined by amplified fragment length polymorphism (AFLP) analysis spa typing. Multilocus sequence typing (MLST) conducted on subset to match AFLP clusters with MLST clonal complexes (CCs). This data set allowed us study estimate extent bovine-to-human transmission. genotype compositions farmers were very similar, while quite distinct. Overall, transmission low, but specific genotypes did show increased cow-to-human Unexpectedly, more than one-third belonged CC8, lineage considered be associated, it well known (i.e., USA300). Despite fact that we detect some other cows no CC8 detected, except for one tentative case. despite close strains nonfarmer strains. These results suggest new bovine-adapted due recent shift humans concurrent loss ability colonize humans. More broadly, our indicate lineage-specific trait can rapidly evolve.