Epidemiology of methicillin-resistant Staphylococcus aureus carrying the novel mecC gene in Denmark corroborates a zoonotic reservoir with transmission to humans

摘要: Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of healthcare-associated (HA), community-associated (CA) and live-stock-associated (LA) infections. Recently, the discovery human bovine MRSA isolates carrying new mecA gene homologue, mecALGA251 (now designated mecC), has caused concern because they are not detected by conventional, confirmatory tests for MRSA. Very little known about their frequency, epidemiology possible transmission between livestock humans. In this study, mecC in Denmark was investigated screening national collections cases (from 1988 onwards) S. bacteraemia 1958 onwards). Isolates were only recovered infrequently before 2003 (n = 2) but now seem to be increasing, with 110 2003–2011. Clinical data on mecC-carrying demonstrated that mecC-MRSA primarily community-acquired (CA-MRSA) affected persons typically living rural areas, being older than other CA-MRSA patients. Among 22 Region Zealand, four reported contact cattle sheep. Two these lived farms positive MRSA, sharing spa type (t843), MLVA (MT429) PFGE pattern isolates. These observations indicate can exchanged humans ruminants.