In Vivo Effect of Flucloxacillin in Experimental Endocarditis Caused by mecC-positive Staphylococcus aureus Showing Temperature-Dependent Susceptibility In Vitro
作者： Stefano Mancini , Frédéric Laurent , Tiago R. Veloso , Marlyse Giddey , Jacques Vouillamoz
DOI: 10.1128/AAC.04733-14
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摘要: Methicillin-resistant Staphylococcus aureus (MRSA) carrying the mecC gene (mecC-MRSA) exhibited at 37°C MICs of oxacillin close to those methicillin-susceptible S. (MSSA). We investigated whether this temperature, mecC-MRSA strains respond flucloxacillin treatment like MSSA strains, using a rat model endocarditis. Flucloxacillin (human-like kinetics 2 g intravenously every 6 h) cured 80 100% aortic vegetations infected with five different strains. These results suggest that infections may successfully β-lactams.
sci-hub.se 参考文章(33)
Frederic Laurent, Hubert Chardon, Marisa Haenni, Michele Bes, Marie-Elisabeth Reverdy, Jean-Yves Madec, Evelyne Lagier, François Vandenesch, Anne Tristan, MRSA harboring mecA variant gene mecC, France. Emerging Infectious Diseases. ,vol. 18, pp. 1465- 1467 ,(2012) , 10.3201/EID1809.111920
Mary Jane. Ferraro, Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically NCCLS. ,(2000)
A. Petersen, M. Stegger, O. Heltberg, J. Christensen, A. Zeuthen, L.K. Knudsen, T. Urth, M. Sorum, L. Schouls, J. Larsen, R. Skov, A.R. Larsen, Epidemiology of methicillin-resistant Staphylococcus aureus carrying the novel mecC gene in Denmark corroborates a zoonotic reservoir with transmission to humans Clinical Microbiology and Infection. ,vol. 19, ,(2013) , 10.1111/1469-0691.12036
E Héraïef, M P Glauser, L R Freedman, Natural history of aortic valve endocarditis in rats. Infection and Immunity. ,vol. 37, pp. 127- 131 ,(1982) , 10.1128/IAI.37.1.127-131.1982
André Kriegeskorte, Britta Ballhausen, Evgeny A. Idelevich, Robin Köck, Alexander W. Friedrich, Helge Karch, Georg Peters, Karsten Becker, Human MRSA Isolates with Novel Genetic Homolog, Germany Emerging Infectious Diseases. ,vol. 18, pp. 1016- 1018 ,(2012) , 10.3201/EID1806.110910
U Fluckiger, P Moreillon, J Blaser, M Bickle, M P Glauser, P Francioli, Simulation of amoxicillin pharmacokinetics in humans for the prevention of streptococcal endocarditis in rats. Antimicrobial Agents and Chemotherapy. ,vol. 38, pp. 2846- 2849 ,(1994) , 10.1128/AAC.38.12.2846
AC Fluit, What to do with MRSA with a novel mec gene Lancet Infectious Diseases. ,vol. 11, pp. 580- 581 ,(2011) , 10.1016/S1473-3099(11)70180-3
M V Madiraju, D P Brunner, B J Wilkinson, Effects of temperature, NaCl, and methicillin on penicillin-binding proteins, growth, peptidoglycan synthesis, and autolysis in methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. ,vol. 31, pp. 1727- 1733 ,(1987) , 10.1128/AAC.31.11.1727
Choonkeun Kim, Catarina Milheiriço, Susana Gardete, Mark A. Holmes, Matt T. G. Holden, Hermínia de Lencastre, Alexander Tomasz, Properties of a Novel PBP2A Protein Homolog fromStaphylococcus aureusStrain LGA251 and Its Contribution to the β-Lactam-resistant Phenotype Journal of Biological Chemistry. ,vol. 287, pp. 36854- 36863 ,(2012) , 10.1074/JBC.M112.395962
B J Hartman, A Tomasz, Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. Journal of Bacteriology. ,vol. 158, pp. 513- 516 ,(1984) , 10.1128/JB.158.2.513-516.1984