Prognostic significance of monocarboxylate transporter expression in oral cavity tumors.
作者： Susana Simões-Sousa , Sara Granja , Céline Pinheiro , Daniela Fernandes , Adhemar Longatto-Filho
DOI: 10.1080/15384101.2016.1188239
关键词:
摘要: ABSTRACTBackground: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of cancer. The majority patients present advanced stage disease has poor survival. Therefore, it imperative to search for new biomarkers alternative effective treatment options. Most cancer cells rely on aerobic glycolysis generate energy metabolic intermediates. This phenotype a hallmark cancer, characterized by an increase in glucose consumption production high amounts lactate. Consequently, need up-regulate many proteins enzymes related with glycolytic metabolism. Thus, aim this study was characterize oral cavity cancers (OCC) assessing expression pattern monocarboxylate transporters (MCTs) 1, 2 4 other phenotype. Material Methods: We evaluated immunohistochemical MCT1, MCT4, CD147, GLUT1 CAIX 135 human samples OCC inv...
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