The role of carbonic anhydrase IX in hypoxia control in OSCC

作者: Mario Pérez-Sayáns , Claudiu T. Supuran , Silvia Pastorekova , José Manuel Suárez-Peñaranda , Gayoso-Diz Pilar

DOI: 10.1111/J.1600-0714.2012.01144.X

关键词:

摘要: Tumoral microenvironments play a key role in the evolution of solid tumors. Tumor hypoxia is actively involved promotion genetic instability, invasive capacity tumor cells, metastasis, and worsening clinical evolution. Endogenous markers are controlled by hypoxia-related genes, formed HIF-1, which related to several target genes that involve energy metabolism, angiogenesis, transmembrane carbonic anhydrases (CAs), mainly CA-IX one tumor-related anhydrases. The goal this paper establish as marker OSCC, while analyzing its expression type tumors relationship with pathological parameters prognosis, evaluating other markers, clarifying chemotherapy radiotherapy resistance.

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