Coexpression of hypoxia-inducible factor-1α and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients.

摘要: Eckert A W, Lautner M H Schutze A, Taubert H, Schubert J & Bilkenroth U (2011) Histopathology58, 1136–1147 Coexpression of hypoxia-inducible factor-1α and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients Aims:  To study whether coexpression the two hypoxia-related proteins factor (HIF)-1α transporter (GLUT)-1 has prognostic relevance carcinomas (OSCCs). Methods results:  Eighty-two OSCC samples were analysed for expression levels HIF-1α GLUT-1 by immunohistochemistry. Protein was assessed an immunoreactive score system, correlations between gene both clinical pathohistological parameters examined. Overexpression either or disease-specific survival patients. Multivariate Cox proportional-hazards regression analysis revealed that increased significantly (relative risk = 3.24, P = 0.024), as compared group a low level expression. Coexpression additively adverse prognoses patients OSCC. Patients whose tumours had found to have 5.13-fold risk tumour-related death (P = 0.017). Conclusions:  high correlated patients, suggesting these can be used early diagnostic independent marker.