Exploiting the biomimetic and luminescence properties of multivalent dendrimer–semiconductor nanohybrid materials in the ultra-low level determination of folic acid

摘要: In view of the enhanced generation folate receptors in cancerous cells and diseases linked to deficiency folic acid, such as anemia, mental devolution, congenital malformation, etc., development a simple method for ultra-sensitive determination acid remains long-standing issue practical applications medicine biotechnology. Thus, proposed luminescence based strategy involving multifunctional poly(amidoamine) (PAMAM) dendrimer encapsulated quantum dots (QDs) probe provides simple, fast efficient selective at nano-molar level. Absorption Fourier transform infra-red (FTIR) spectroscopy provide evidence binding with amine groups. The emission quenching CdS QDs follows linear Stern-Volmer plot an exceedingly high value constant (KSV = 8.4 × 106 M-1) facilitating higher detection efficiency. Similar analysis dendrimer-ZnS showed slightly lower 2.29 M-1). probing efficiency protein or amino capping has been explained through zeta potential measurements. solvent polarity dependence suggests charge transfer process responsible QDs, which is static nature revealed by lifetime this low level not affected possible interfering molecules, vitamin C, B12 uric acid. Calorimetric measurements that exothermic enthalpy-entropy compensation. detailed mechanistic aspect interactions QD helps better understanding process, turn can assist developing material image drug delivery receptor rich cells.