Measurement of circulating transcript levels (NETest) to detect disease recurrence and improve follow‐up after curative surgical resection of well‐differentiated pancreatic neuroendocrine tumors

摘要: Background: Recurrence of pancreatic neuroendocrine tumors (pNET) after surgery is common. Strategies to detect recurrence have limitations. We investigated the role clinical criteria and multigene polymerase chain reaction–based NETest during post-operative follow-up pNET. Methods: studied 3 groups resections: R0 with no (n = 11), R0 with 12), R1 12). levels (>40%) were compared chromogranin A (CgA) clinicopathological (CC; grade, lymph node metastases, size). Nonparametric, receiver operating characteristics, logistic regression, predictive feature importance analyses performed. Results: was higher in (56 ± 8%) (39 6%) (28 6%, P <.005). positively correlated (area under curve: 0.82), CgA not 0.51 0.09). Multiple regression analysis defined factor impact as highest for (P <.005) versus CC <.03) =.23). gave false positive or negative 18% using a 40% cutoff. Logistic modeling 83% accurate; it 91% when included. Combining approximately 2× more effective than individual alone (increase in R 2 value from 43% 80%). Conclusions: blood test facilitates identification pNET recurrence, prediction disease relapse, outperforms CgA.