Expression of steroid hormone receptors in benign hepatic tumors. An immunocytochemical study.

摘要: Many hepatic adenomas have been demonstrated to a clear relationship with oral contraceptive use, and it is presumed that there may be hormone receptors within the cytoplasm or nucleus of adenoma cells mediate tumor growth in response hormonal stimulation. Only small number examples benign tumors analyzed for presence estrogen progesterone receptors, has lack consensus regard findings. All previous studies determined receptor levels by biochemical methods. In retrospective study, we employed specific monoclonal antibodies against 10 paraffin-embedded lesions: five focal nodular hyperplasia. patients were female, except one male No patient had received tamoxifen citrate any other form therapy their lesion. Positive controls included malignant breast tissue. positive staining was seen adenoma, hyperplasia, normal adjacent liver parenchyma. Intense all control tissues. This negative result use an established immunohistochemical method analysis does not exclude these lesions, but suggest that, if present, they occur much smaller amounts than The deserves further study.