作者: Alan Brunelle , Stephen Turner , Cathy Federici , Michael Hite
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摘要: The present invention is a solid dosage form for oral administration of ibuprofen comprising modified release formulation which provides an immediate burst effect and thereafter sustained sufficient to maintain blood levels at least 6.4 µg/ml over extended period 8 hours following single dose. releases rate initially deliver effective amount within about 2.0 administration. then subsequently delivers the remaining relatively constant level predetermined delivery hours.