作者: Chih-Ming Chen
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摘要: A once-a-day diltiazem dosage form which comprises: (a) a core element is compressed tablet contains therapeutic dose of and an amount solubility modulating substance that controls the release said in order to provide level over period about 24 hours; (b) on outer surface element, sufficient enteric coating causes at rate permits use dosing maintain steady state levels diltiazem.