Controlled absorption diltiazem formulations

摘要: A diltiazem pellet formulation for oral administration comprises a core of or pharmaceutically acceptable salt thereof in association with an organic acid and lubricant, membrane surrounding the comprising multiplicity sequentially applied dried layers, each layer containing major proportion film-forming, water insoluble, naturally occurring polymer minor soluble polymer. The number layers ratio to insoluble being effective permit release from at rate allowing controlled absorption over twelve hour period following administration.