Sustained absorption pharmaceutical composition
作者： Donald Eugene Panoz , Edward James Geoghegan
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摘要: A sustained absorption theophylline-containing pellet for oral administration comprises a core of theophylline or pharmacological equivalent thereof and an organic acid embedded in polymeric material multi-layer arrangement outer membrane which permits release the at controlled rate aqueous medium. The has dissolution vitro medium, when measured basket assembly according to U.S. Pharmacopoeia XX 37° C. 75 r.p.m., is not more than 15% total after 2 hours measurement buffer solution pH 7.5. Not 35% released 7 65% 13 hours.
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