Diltiazem controlled release formulation
作者： Chih-Ming Chen
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摘要: A once-a-day controlled release diltiazem formulation is described which includes: (a) from 20 to 50 % by weight of enteric polymeric membrane coated pellets comprising a polymer core comprises biologically inert with first layer consists essentially and binder; second pH dependent material; (b) 80 delayed pulse binder will substantially maintain its integrity in the varying conditions gastrointestinal tract but permeable diltiazem; (c) unit dose containment system.
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