Rate of immune complex cycling in follicular dendritic cell determines the extent of protecting antigen integrity and availability to germinal center B cells1
作者： Theinmozhi Arulraj , Sebastian C. Binder , Michael Meyer-Hermann
DOI: 10.1101/2020.11.27.401315
关键词:
摘要: Follicular Dendritic Cells (FDCs) retain immune complexes (ICs) for prolonged time periods and are important germinal center (GC) reactions. ICs undergo periodic cycling in FDCs, a mechanism supporting an extended half-life of antigen. Based on experimental data we estimated that the average residence Phycoerythrin-ICs (PE-ICs) FDC surface interior were 21 36 minutes, respectively. GC simulations show antigen might impact dynamics due to redistribution by protecting from degradation. Antigen protection influence varied with total concentration. Simulations predict blocking terminates reaction decreases plasma cell production. Considering could be target modulation reactions, our findings highlight importance understanding regulation IC FDCs.
sci-hub.st 参考文章(63)
Follicular stromal cells and lymphocyte homing to follicles. Immunological Reviews. ,vol. 176, pp. 181- 193 ,(2000) , 10.1034/J.1600-065X.2000.00618.X
T K van den Berg, C D Dijkstra, K Yoshida, Two functionally different follicular dendritic cells in secondary lymphoid follicles of mouse spleen, as revealed by CR1/2 and FcR gamma II-mediated immune-complex trapping. Immunology. ,vol. 80, pp. 34- 39 ,(1993)
Dahui Qin, Jiuhua Wu, Kalpit A. Vora, Jeffrey V. Ravetch, Andras K. Szakal, Tim Manser, John G. Tew, Fc gamma receptor IIB on follicular dendritic cells regulates the B cell recall response. Journal of Immunology. ,vol. 164, pp. 6268- 6275 ,(2000) , 10.4049/JIMMUNOL.164.12.6268
J G Tew, T E Mandel, P L Rice, Immune elimination and immune retention: the relationship between antigen retained in the foot and the elicitation of footpad swelling. Immunology. ,vol. 40, pp. 425- 433 ,(1980)
Marie H. Kosco-Vilbois, Are follicular dendritic cells really good for nothing Nature Reviews Immunology. ,vol. 3, pp. 764- 769 ,(2003) , 10.1038/NRI1179
David Gray, A role for antigen in the maintenance of immunological memory Nature Reviews Immunology. ,vol. 2, pp. 60- 65 ,(2002) , 10.1038/NRI706
J. G. Tew, T. E. Mandel, Prolonged antigen half-life in the lymphoid follicles of specifically immunized mice Immunology. ,vol. 37, pp. 69- 76 ,(1979)
Michael Meyer-Hermann, Overcoming the Dichotomy of Quantity and Quality in Antibody Responses Journal of Immunology. ,vol. 193, pp. 5414- 5419 ,(2014) , 10.4049/JIMMUNOL.1401828
J V Ravetch, T Manser, K A Vora, Amplified follicular immune complex deposition in mice lacking the Fc receptor gamma-chain does not alter maturation of the B cell response. Journal of Immunology. ,vol. 159, pp. 2116- 2124 ,(1997)
Anna Bolduc, Eugene Long, Dale Stapler, Marilia Cascalho, Takeshi Tsubata, Pandelakis A. Koni, Michiko Shimoda, Constitutive CD40L Expression on B Cells Prematurely Terminates Germinal Center Response and Leads to Augmented Plasma Cell Production in T Cell Areas Journal of Immunology. ,vol. 185, pp. 220- 230 ,(2010) , 10.4049/JIMMUNOL.0901689