Thermodynamics and Cancer Dormancy: A Perspective
作者： Edward A. Rietman , Jack A. Tuszynski
DOI: 10.1007/978-3-319-59242-8_5
关键词:
摘要: In this review we elaborate on the hypothesis that concepts adapted from statistical thermodynamics, such as entropy and Gibbs free energy, can provide very powerful quantitative measures when applied to cancer research, in particular dormancy. We discuss how all size scales of biological organization hierarchy DNA tissue organ representation, progression be correlated with these thermodynamic measures. Significant diagnostic, prognostic therapeutic implications new organizing principles are presented.
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sci-hub.se 参考文章(51)
Marcella Boveri, Theodor Boveri, The origin of malignant tumors Williams & Wilkins. ,(1929)
Irina Kareva, Faina Berezovskaya, Cancer immunoediting: A process driven by metabolic competition as a predator–prey–shared resource type model Journal of Theoretical Biology. ,vol. 380, pp. 463- 472 ,(2015) , 10.1016/J.JTBI.2015.06.007
Chih-Yuan Tseng, Jack Tuszynski, A unified approach to computational drug discovery. Drug Discovery Today. ,vol. 20, pp. 1328- 1336 ,(2015) , 10.1016/J.DRUDIS.2015.07.004
Sebastian Benzekry, Jack A. Tuszynski, Edward A. Rietman, Giannoula Lakka Klement, Design principles for cancer therapy guided by changes in complexity of protein-protein interaction networks Biology Direct. ,vol. 10, pp. 32- 32 ,(2015) , 10.1186/S13062-015-0058-5
Sune Danø, Preben Graae Sørensen, Finn Hynne, Sustained oscillations in living cells Nature. ,vol. 402, pp. 320- 322 ,(1999) , 10.1038/46329
Weinan E, Jianfeng Lu, Yuan Yao, The Landscape of Complex Networks arXiv: Methodology. ,(2012)
Narayana Battula, Lawrence A. Loeb, Clark F. Springgate, Errors in DNA Replication as a Basis of Malignant Changes Cancer Research. ,vol. 34, pp. 2311- 2321 ,(1974)
Nicolas Carels, Tatiana Martins Tilli, Jack A. Tuszynski, Optimization of combination chemotherapy based on the calculation of network entropy for protein-protein interactions in breast cancer cell lines EPJ Nonlinear Biomedical Physics. ,vol. 3, pp. 6- ,(2015) , 10.1140/EPJNBP/S40366-015-0023-3
Douglas E. Friesen, Vickie E. Baracos, Jack A. Tuszynski, Modeling the energetic cost of cancer as a result of altered energy metabolism: implications for cachexia. Theoretical Biology and Medical Modelling. ,vol. 12, pp. 17- 17 ,(2015) , 10.1186/S12976-015-0015-0
M. A. Nowak, N. L. Komarova, A. Sengupta, P. V. Jallepalli, I.-M. Shih, B. Vogelstein, C. Lengauer, The role of chromosomal instability in tumor initiation. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 16226- 16231 ,(2002) , 10.1073/PNAS.202617399