Prevalence of p53 codon 72, p73 G4C14-A4T14 and MDM2 T309G polymorphisms and its association with the risk of oral cancer in South Indians
作者： Arunagiri Kuha Deva Magendhra Rao , Mayakannan Manikandan , Ganesan Arunkumar , Sundaramoorthy Revathidevi , Vilvanathan Vinothkumar
DOI: 10.1016/J.GENREP.2017.03.003
关键词:
摘要: Abstract Background and aim Genetic susceptibility to cancer through single nucleotide polymorphisms - p53 Pro72Arg, p73 G4C14-A4T14 (two linked polymorphism) MDM2 T309G has been reported in various ethnic populations. Yet the association is unclear oral of Indian origin where tobacco chewing widely practiced. The study was evaluate significance these for development cancer. Materials methods Single Nucleotide Polymorphisms were genotyped 204 cases 212 unrelated controls by allele specific polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) methods. Results Our results indicate high prevalence Pro72 [28.92%] patients an with [OR = 3.72, 95%CI = 1.697–8.143, p Conclusion We conclude P53 Proline confers risk developing when
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