Interaction of HLA and Gm in autoimmune chronic active hepatitis.

摘要: An immunogenetic study of autoimmune chronic active hepatitis (CAH) showed the relative risk (RR) for this disease was 11.6 patients who were HLA-B8, 11.7 DR3 and 2.3 Gma+x+. Moreover, Gm haplotype Gma+x+ present in 18 40 (45%) with but none 10 negative whereas 180 healthy controls evenly distributed among those positive (24%) (18%) HLA-B8. The RR lowest lacking HLA-B8 Relative to low-risk group, increased 39 times subjects both Gma+x+, 15 not twice neither nor Statistical analysis indicated that three-factor effect (disease affected by non-additive effects Gma+x+) significant (P less than 0.01), as main 0.001) 0.02). Thus presence genes linked an immunoglobulin CH allotype, may contribute development hepatitis; absence these same appear be inactive. This indicate interactions between MHC gene products VH presentation recognition autoantigen(s) hepatitis.