Cytomegalovirus- and interferon-related effects on human endothelial cells: Cytomegalovirus infection reduces upregulation of HLA class II antigen expression after treatment with interferon-γ
作者： Martin Scholz , Annette Hamann , Roman A. Blaheta , Marcus K.H. Auth , Albrecht Encke
DOI: 10.1016/0198-8859(92)90004-7
关键词:
摘要: Cultured human umbilical vein endothelial cells (HUVEs) were infected with cytomegalovirus (HCMV) strain AD169. Up to 50% HUVEs proved be positive for HCMV early nuclear antigens 24 hours after inoculation virus. Following infection kinetics of surface expression HLA class I and II, intercellular adhesion molecule (ICAM-1) lymphocyte (ELAM-1) on investigated by means flow cytometry. A slight increase in was observed, whereas II (DR, DP, DQ) not induced HCMV. Furthermore, when compared uninfected treated interferon-gamma (IFN-gamma), reduced enhancement HLA-DR conspicuous HCMV-infected IFN-gamma. There is evidence that only a portion HUVE affected its ability upregulate antigens. While ICAM-1 found enhanced between 8 20 maximum at 12 infection, no modulation ELAM-1 seen.
sci-hub.se 参考文章(53)
L. Makowka, S. Saidman, B. Markus, T.E. Starzl, A.J. Demetris, R. Duquesnoy, J. Fung, Establishment of Primary Cultures of Human Biliary Epithelium and Induction of Class II Major Histocompatibility Complex Antigens by Interferon Gamma. Transplantation proceedings. ,vol. 20, pp. 728- 730 ,(1988)
R Levy, L A Lampson, Two populations of Ia-like molecules on a human B cell line. Journal of Immunology. ,vol. 125, pp. 293- 299 ,(1980)
J S Pober, J Doukas, IFN-gamma enhances endothelial activation induced by tumor necrosis factor but not IL-1. Journal of Immunology. ,vol. 145, pp. 1727- 1733 ,(1990)
E S Huang, S Haskill, B D Clark, P E Auron, S Sporn, L Dudding, Cytomegalovirus infection stimulates expression of monocyte-associated mediator genes. Journal of Immunology. ,vol. 143, pp. 3343- 3352 ,(1989)
C Power, R M Edwards, C Walker, L A Needham, R Pigott, Structural and functional studies of the endothelial activation antigen endothelial leucocyte adhesion molecule-1 using a panel of monoclonal antibodies. Journal of Immunology. ,vol. 147, pp. 130- 135 ,(1991)
C A Gleaves, T F Smith, E A Shuster, G R Pearson, Rapid detection of cytomegalovirus in MRC-5 cells inoculated with urine specimens by using low-speed centrifugation and monoclonal antibody to an early antigen. Journal of Clinical Microbiology. ,vol. 19, pp. 917- 919 ,(1984) , 10.1128/JCM.19.6.917-919.1984
E G Engleman, J R Bender, R Pardi, Lymphocyte subsets differentially induce class II human leukocyte antigens on allogeneic microvascular endothelial cells. Journal of Immunology. ,vol. 139, pp. 2585- 2592 ,(1987)
Jordan S Pober, Tucker Collins, Michael A Gimbrone Jr, Ramzi S Cotran, Jonathan D Gitlin, Walter Fiers, Carol Clayberger, Alan M Krensky, Steven J Burakoff, Carol S Reiss, None, Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. Nature. ,vol. 305, pp. 726- 729 ,(1983) , 10.1038/305726A0
JS Pober, MA Gimbrone Jr, T Collins, RS Cotran, KA Ault, W Fiers, AM Krensky, Carol Clayberger, Carol S Reiss, SJ Burakoff, None, Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens Immunobiology. ,vol. 168, pp. 483- 494 ,(1984) , 10.1016/S0171-2985(84)80132-1
Sohan L. Gupta, Regulation of cellular gene expression by interferon-gamma: involvement of multiple pathways. Stem Cells. ,vol. 8, pp. 92- 102 ,(1990) , 10.1002/STEM.5530080709