Innate Immunity and Human Milk

摘要: Human neonates are born with an immature and naive acquired immune system, many of the innate components mucosal immunity not fully developed. Thus, system human milk is important complement to barrier developing gut. The nursing mother provides her infant protective agents through milk, a growing number which have been identified as isolates in laboratory models infection. number, potency, importance these probably greater than previously thought. For example, potent found until digestion releases antimicrobial such fatty acids peptides. An alternate conformer alpha-lactalbumin forms from stomach inhibits cancer cells. Many constituents inhibit different aspects pathogenic process, creating synergy, where much lower concentrations each component become protective. Some temporal spatial specificity that would cause their role go unrecognized by most had remained underappreciated because technical challenges isolation testing. Recent reports suggest contains highly mixture constitute whereby protects enteric other diseases. These human-milk may represent rich source novel classes therapeutic against pathogens.