General Approach to Molecular Pathology

摘要: Once a highly specialized subdiscipline of laboratory medicine, molecular diagnostics now infiltrates all anatomic and clinical pathology. The shift from dependence on few, relatively cumbersome methods to wider range technologies has facilitated this expansion. In addition, the completion Human Genome Project growing amount sequence data related infection, cancer, other disease states have yielded additional applications biology for (Figure 7.1). As various phases testing can be automated in many instances, biologic experience is no longer prerequisite. fact, performance nucleic acid extraction amplification tabletop unit possible.1, 2 Increasingly, miniaturization will further move point care.3 Open image new window Figure 7.1 Molecular encompasses use acids diagnose malignancy (hematologic solid tumors), genetic diseases. Other major foci include investigation human remains crime scenes (forensics) evaluation transplant donors recipients (human leukocyte antigen [HLA] testing).