T-cell receptor gene therapy e ready to go viral? 5

摘要: T lymphocytes can be redirected to recognize a tumor target and harnessed combat cancer by genetic introduction of T-cell receptors defined specificity. This approach has recently mediated encouraging clinical responses in patients with cancers previously regarded as incurable. However, despite the great promise, receptor gene therapy still faces multitude obstacles. Identification epitopes that enable effective targeting all cells heterogeneous while sparing normal tissues remains perhaps most demanding challenge. Experience from trials revealed dangers associated highlighted need for reliable preclinical methods identify potentially hazardous recognition both intended unintended healthy tissues. Procedures manufacturing large highly potent populations optimized enhance their antitumor efficacy. Here, we review current knowledge gained models using adoptive transfer receptor-engineered lymphocytes, discuss major challenges involved highlight potential strategies increase safety efficacy make standard-of-care patient groups.