Phenotypic alteration of eukaryotic cells using randomized libraries of artificial transcription factors.

作者: Kyung-Soon Park , Dong-ki Lee , Horim Lee , Yangsoon Lee , Young-Soon Jang

DOI: 10.1038/NBT868

关键词:

摘要: … Here we describe an approach for altering phenotypes of eukaryotic cells with combinatorial libraries of artificial transcription factors. We used a pool of individual zinc fingers with …

参考文章(44)
Marianne D. De Backer, Bart Nelissen, Marc Logghe, Jasmine Viaene, Inge Loonen, Sandy Vandoninck, Ronald de Hoogt, Sylviane Dewaele, Fermin A. Simons, Peter Verhasselt, Greet Vanhoof, Roland Contreras, Walter H.M.L. Luyten, An antisense-based functional genomics approach for identification of genes critical for growth of Candida albicans Nature Biotechnology. ,vol. 19, pp. 235- 241 ,(2001) , 10.1038/85677
Scot A. Wolfe, Lena Nekludova, Carl O. Pabo, DNA recognition by Cys2His2 zinc finger proteins. Annual Review of Biophysics and Biomolecular Structure. ,vol. 29, pp. 183- 212 ,(2000) , 10.1146/ANNUREV.BIOPHYS.29.1.183
Takenobu Katagiri, Akira Yamaguchi, Motohiro Komaki, Etsuko Abe, Naoyuki Takahashi, Tohru Ikeda, Vicki Rosen, John M Wozney, Atsuko Fujisawa-Sehara, Tatsuo Suda, Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. Journal of Cell Biology. ,vol. 127, pp. 1755- 1766 ,(1994) , 10.1083/JCB.127.6.1755
Wayne E. Taylor, Hubert K. Suruki, Amy Hsiu Ti Lin, Pejman Naraghi-Arani, Robert Y. Igarashi, Maziar Younessian, Pamela Katkus, Nam V. Vo, Designing Zinc-Finger ADR1 Mutants with Altered Specificity of DNA Binding to T in UAS1 Sequences Biochemistry. ,vol. 34, pp. 3222- 3230 ,(1995) , 10.1021/BI00010A011
John R. Desjarlais, Jeremy M. Berg, Redesigning the DNA-binding specificity of a zinc finger protein: a data base-guided approach. Proteins. ,vol. 12, pp. 101- 104 ,(1992) , 10.1002/PROT.340120202
M. Kruger, C. Beger, Q.-X. Li, P. J. Welch, R. Tritz, M. Leavitt, J. R. Barber, F. Wong-Staal, Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 8566- 8571 ,(2000) , 10.1073/PNAS.97.15.8566
Eiichi Morii, Keisuke Oboki, Tatsuki R. Kataoka, Kazuhiko Igarashi, Yukihiko Kitamura, Interaction and Cooperation of mi Transcription Factor (MITF) and Myc-associated Zinc-finger Protein-related Factor (MAZR) for Transcription of Mouse Mast Cell Protease 6 Gene Journal of Biological Chemistry. ,vol. 277, pp. 8566- 8571 ,(2002) , 10.1074/JBC.M110392200
Jin-Soo Kim, Carl O. Pabo, Transcriptional Repression by Zinc Finger Peptides Journal of Biological Chemistry. ,vol. 272, pp. 29795- 29800 ,(1997) , 10.1074/JBC.272.47.29795
Peter J. Welch, Eric G. Marcusson, Qi-Xiang Li, Carmela Beger, Martin Krüger, Chen Zhou, Mark Leavitt, Flossie Wong-Staal, Jack R. Barber, Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes. Genomics. ,vol. 66, pp. 274- 283 ,(2000) , 10.1006/GENO.2000.6230