Correlated quantitative studies of the neostriatum, nucleus accumbens, substantia nigra, and ventral tegmental area in normal and weaver mutant mice
作者： SA Bayer , LC Triarhou , JD Thomas , B Ghetti
DOI: 10.1523/JNEUROSCI.14-11-06901.1994
关键词:
摘要: Normal mice (+/+) and homozygous weaver mutant (wv/wv) at 1 year of age were used for three-dimensional computer-aided reconstructions the nucleus accumbens (NA) neostriatum (ST) quantitative estimations total number medium-sized neurons in NA ST, tyrosine hydroxylase (TH)-containing ventral tegmental area (VTA) substantia nigra (SN). The showed that ST are smaller than they +/+. Quantitative volumetric measurements wv/wv +/+ by nonsignificant differences 14% 13%, respectively. group statistically significant depletion all four structures. On average, reduced 27%, 22%, VTA-TH 40%, SN-TH 79%. In animals, there was a high positive correlation (r = 0.836) between numbers moderate 0.534) SN-VTA neurons. nuclei TH-containing had same diameters, but contained larger Cytoarchitectonic control also similar. contains more densely packed with those ST.
sci-hub.st 参考文章(29)
S Roffler-Tarlov, D Pugatch, AM Graybiel, Patterns of cell and fiber vulnerability in the mesostriatal system of the mutant mouse weaver. II. High affinity uptake sites for dopamine The Journal of Neuroscience. ,vol. 10, pp. 734- 740 ,(1990) , 10.1523/JNEUROSCI.10-03-00734.1990
MJ Schmidt, BD Sawyer, KW Perry, RW Fuller, MM Foreman, B Ghetti, Dopamine deficiency in the weaver mutant mouse The Journal of Neuroscience. ,vol. 2, pp. 376- 380 ,(1982) , 10.1523/JNEUROSCI.02-03-00376.1982
Charles R. Gerfen, William A. Staines, Hans C. Fibiger, Gordon W. Arbuthnott, Crossed connections of the substantia nigra in the rat. The Journal of Comparative Neurology. ,vol. 207, pp. 283- 303 ,(1982) , 10.1002/CNE.902070308
A. Kalsbeek, R.M. Buijs, M.A. Hofman, M.A.H. Matthijssen, C.W. Pool, H.B.M. Uylings, Effects of neonatal thermal lesioning of the mesocortical dopaminergic projection on the development of the rat prefrontal cortex Developmental Brain Research. ,vol. 32, pp. 123- 132 ,(1987) , 10.1016/0165-3806(87)90145-3
J�rn Carlsen, Jose de Olmos, Lennart Heimer, Tracing of two-neuron pathways in the olfactory system by the aid of transneuronal degeneration: Projections to the amygdaloid body and hippocampal formation The Journal of Comparative Neurology. ,vol. 208, pp. 196- 208 ,(1982) , 10.1002/CNE.902080208
Patricia L. Mensah, The internal organization of the mouse caudate nucleus: Evidence for cell clustering and regional variation Brain Research. ,vol. 137, pp. 53- 66 ,(1977) , 10.1016/0006-8993(77)91012-5
Haring J.W. Nauta, Michael B. Pritz, Raymond J. Lasek, Afferents to the rat caudoputamen studied with horseradish peroxidase. An evaluation of a retrograde neuroanatomical research method Brain Research. ,vol. 67, pp. 219- 238 ,(1974) , 10.1016/0006-8993(74)90274-1
G. James Royce, Cells of origin of subcortical afferents to the caudate nucleus: A horseradish peroxidase study in the cat Brain Research. ,vol. 153, pp. 465- 475 ,(1978) , 10.1016/0006-8993(78)90332-3
I. A. Hendry, A method to correct adequately for the change in neuronal size when estimating neuronal numbers after nerve growth factor treatment. Journal of Neurocytology. ,vol. 5, pp. 337- 349 ,(1976) , 10.1007/BF01175119
M. Herkenham, S. Moon Edley, J. Stuart, Cell clusters in the nucleus accumbens of the rat, and the mosaic relationship of opiate receptors, acetylcholinesterase and subcortical afferent terminations Neuroscience. ,vol. 11, pp. 561- 593 ,(1984) , 10.1016/0306-4522(84)90045-9