Nanoencapsulated betulinic acid analogue distinctively improves colorectal carcinoma in vitro and in vivo.

摘要: Betulinic acid, a plant secondary metabolite, has gained significant attention due to its antiproliferative activity over range of cancer cells. A promising betulinic acid analogue (2c) with better therapeutic efficacy than parent molecule colon carcinoma cells been reported. Despite impressive biological applications, low aqueous solubility and bioavailability create difficulties for applications. To overcome these lacunae make it as drug candidate we have encapsulated the lead derivative in polymeric nanocarrier system (2c-NP) evaluated vitro vivo efficacy. Apoptosis that induces was significantly increased by 2c-NP compared free-drug (2c), assured MTT assay, Annexin V positivity, JC1 analysis cell cycle study. The therapeutic potential measured reflects ability an effective agent treatment future translation clinical trials.