Effects of Pacing on Stationary Reentrant Activity: Theoretical and Experimental Study

摘要: Abstract It is well known that electrical pacing may either terminate or change the rate and/or ECG appearance of reentrant ventricular tachycardia. However, dynamics interaction waves with initiated by external are poorly understood. Prevailing concepts based on simplistic models in which propagation occurs one-dimensional rings cardiac tissue. Since activation ventricles two three dimensions, such might be insufficient to explain mechanisms pacing-induced effects. We used numerical and biological excitation explore phenomena, take place as a result during functionally determined reentry. Computer simulations two-dimensional array electrically coupled FitzHugh-Nagumo cells were predict response patterns expected from thin slices sheep epicardial muscle, self-sustaining activity form spiral was...