摘要: In summary, the last decade has been a highly fertile and productive period in quinolone medicinal chemistry, resulting major improvements potency, antibacterial spectra, oral absorption pharmacokinetic properties as well an increased knowledge of molecular features important to conferring these various properties. Very recent discoveries concerning replacements for 3-carboxylic acid moiety, previously thought be uniquely essential activity, give potent antibacterials such (83) illustrate potential new breakthroughs this field. Among goals future research remains understanding cartilage toxicity associated with class agents, that agent useful pediatric indications may developed. Future studies can also expected further enhance refine level current insight into manner by which agents inhibit target enzyme on level.
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