Synthesis and biological properties of N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid dipeptides, a novel group of antimicrobial agents.

摘要: A series of dipeptides with N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), the irreversible inhibitor glucosamine-6-phosphate synthetase from bacteria and fungi, have been synthesized their antibacterial antifungal properties in vitro evaluated. The results demonstrate that these peptides inhibit growth a number tested microorganisms, especially pathogenic fungus Candida albicans. competitive antagonism studies indicate specific peptide transport via permeases as drug delivery system gives evidence for high selectivity action upon cells, result inhibition generation glucosamine.